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8.14. Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs

C Yang , T Sheng , W Hou , J Zhang , L Cheng , H Wang , W Liu , S Wang , X Yu , Y Zhang , J Yu , Z Gu

Brief summary: In this experimental study, a transdermal polymeric microneedle (MN) patch for glucose-responsive closed-loop insulin and glucagon delivery was developed. In chemically-induced type 1 diabetes (T1D) mouse and minipig models, this glucose-responsive dual-hormone MN patch demonstrated tight regulation in blood glucose.The interplay between insulin and glucagon is essential for blood glucose regulation in individuals with or without diabetes....

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ey0019.12-11 | Hyperlipidemia | ESPEYB19

12.11. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

H. Wang J, Zhao J, Yan C, Xi C, Wu C, Zhao J, Li F, Ding Y, Zhang R, Qi S, Li X, Liu C, Hou W, Chen H, Wang Y, Wu D, Chen K, Jiang H, Huang H, Liu

Cell Metabolism 2022;34(5):667-80.e6. doi: 10.1016/j.cmet.2022.03.006Brief Summary: In preclinical models and a phase 1 trial, a powerful new lipid small molecule was shown to act through a mechanism distinct from those of known hypolipidemic agents. Targeting HNF-1α may be a new therapeutic strategy.Comment: Familial hypercholesterolemia (FH) is the most common...

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ESPE Yearbook of Paediatric Endocrinology

8.14. Glucose-responsive microneedle patch for closed-loop dual-hormone delivery in mice and pigs

12.11. Identification and evaluation of a lipid-lowering small compound in preclinical models and in a Phase I trial

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